Death receptor signaling and IAPs

Chairs: Martin Leverkus & Giorgio Stassi

9:00    Mathieu JM Bertrand: An NF-kB-independent role of IKKs in regulating RIPK1 killing potential

9:15    Rebecca Feltham: MIB and SOB1 are novel RIPK1 interacting molecules that regulate TNF signaling by controlling the balance between survival and death

9:30    Thomas Grabinger: Mechanisms of TNF induced cell death in intestinal epithelial cells

9:45    Martin Leverkus: cFLIP regulates skin homeostasis and protects from  TNF-induced keratinocyte apoptosis

10:00  Joel S Riley: Identification of novel regulators of FLIP’s ubiquitination and degradation

10:15  Lynn Wong: IAPs and RIPKs modulate sensitivity to TNF induced apoptosis and cancer formation

10:30                      Coffee break

Ubiquitin and IAPs            

Chairs: Pascal Meier & Mads Gyrd-Hansen

11:00 Pascal Meier: Regulation of the ubiquitin E3 ligase cIAP1

11:15  Kate Lawlor: IAP proteins repress spontaneous inflammatory joint disease

11:30  Simone Wicki: Role of XIAP in murine neutrophils downstream of death receptors and in response to danger signals

11:45  Anna Aalto: Characterization of M1-linked linear ubiquitylation in NF-kappaB signaling in Drosophila

12:00: Solange Desagher: Reciprocal regulation of Trim17 and NFATc3: implication in neuronal apoptosis

12:15  Mads Gyrd-Hansen: The deubiquitinase OTULIN regulates LUBAC function and NF-kappaB activation through a direct interaction with HOIP

13:00                      Lunch

         social afternoon