Autophagy and the lysosome
Chairs: Monika Mortensen & Cristina Munoz-Pinedo
9:00 Monika Mortensen: short introduction
9:10 Tom Riffelmacher: Autophagy controls terminal differentiation of neutrophils
9:25 Anne Louise Hansen: Autophagy controls inflammation in the aging organism
9:40 Ghadir Almuhaini: HPV E6 Modulation of Autophagy
9:55 Sonja Aits: Galectins-1 as a novel marker for lysosomal membrane permeabilization
10:10 Søren Høgh: Regulation of lysosomal cell death by lysosomal ions and the TRPML1 ion channel
10:25 Coffee break
Cell death in the immune system
Chairs: Gustavo P. Amarante-Mendes & Huseyin Mehmet
11:00 Julian Pardo : Fast and efficient in vivo elimination of chemoresistant leukemia cells overexpressing Bcl-XL by granzyme B of cytotoxic T cells
11:15 Maykel Arias: During a bacterial infection cytotoxic T cells employ the pro-apoptotic protease granzyme B to eradicate bacteria meanwhile inflammation induced by NK-derived granzyme A causes sepsis
11:30 Gustavo P. Amarante-Mendes: Novel role for galectin-1 in CTL killing
11:45 Anja Krippner-Heidenreich: Dendritic cell survival and maturation are differentially regulated by TNF receptors 1 and 2
12:00 Selma Tuzlak: Analysis of the role of anti-apoptotic A1/Bfl-1 in experimental autoimmune encephalomyelitis
13:00 Lunch
Necroptosis and inflammation
Chairs: Seamus J. Martin & John Silke
15:00 Seamus J. Martin: Crosstalk between Cell Death and Inflammatory Signaling: Challenging Preconceptions
15:15 Scott McComb: Type-I Interferon Signalling is Necessary for Inflammatory Necroptosis of Macrophages
15:30 Monica Yabal: XIAP restricts TNF-dependent necroptosis and excessive inflammasome activation
15:45 Svetlana Saveljeva: Mechanism of ER Stress-Induced Necroptosis
16:00 Tania Løve Aaes: Necroptosis, a novel approach for cancer therapy?
16:15 Fumiyo Ikeda: Sharpin prevents TNFR1-induced keratinocyte apoptosis and skin inflammation by linear ubiquitination of FADD
16:30 Coffee break
Inflammation and NF-kappaB
Chairs: Seamus J. Martin & John Silke
17:00 John Silke: At the crossroad of inflammation and cell death – is there a therapeutic angle?
17:15 Mar Orzaez: Identification of new inflammasome inhibitors targeting ASC-mediated caspase-1 activation
17:30 Karina Bortoluci: Role of lysosomal pathway induced by cytosolic flagellin in cell death and immunity
17:45 Dagmar Kulms: Identification of new IkBa complexes by an iterative experimental and mathematical modeling approach
18:00 Nima Etemadi: TRAF2 regulates canonical and non canonical NFkB signalling to inhibit cell death and inflammation in skin independently of Sphingosine Kinase 1
18:15 Tom Vanden Berghe: Simultaneous targeting of Interleukin-1 and -18 is required for protection against inflammatory and septic shock
19:00 Dinner
20:30 Poster session 2 – odd-numbered posters