7:00 – 9:00 Breakfast 9:00 – 10:15 Caspases & Death domain folds (Lisa Bouchier-Hayes / Brian Ferguson) Susan Logue: Proteomics–based identification of novel substrates for the inflammatory caspases Maarten Hoek: Identification of proteolytic events in the membrane fraction of apoptotic cells using a quantitative proteomics approach Brian Ferguson: AIRE and SP100 define a novel nuclear family of CARD […]
7:00 – 9:00 Breakfast 9:00 – 10:30 Sensitising Cancer to apoptosis (Paul Ekert / Vincenzo De Laurenzi) Michael Bots: Apaf-1 and caspase-9 are dispensable for HDACi– induced cell death of B cell lymphoma Annelieke Jaspers: c-Abl Kinase inhibitors overcome CD40- mediated drug resistance in CLL; implications for therapeutic targeting of chemoresistant niches Michela Muscolini: Trichostatin A up-regulates p73 […]
7:00 – 9:00 Breakfast 9:00 – 10:15 Role of IAPs in physiology and disease (Pascal Meier / Martin Leverkus) Ueli Nachbur: A physiological role for IAPs? Meike Broemer: Ubiquitin-mediated regulation of caspases by DIAP1 Mads Gyrd- Hansen: A conserved ubiquitin-binding domain links Inhibitor of Apoptosis Proteins to NF-kB signalling and cell survival Martin Leverkus: The Inhibitor-of-apoptosis (IAP) protein family […]
9.00-10.45 Nuclear Aspects of “Death” Vincenzo De Laurenzi: FLASH is an essential component of cajal bodies and is required for histone transciption and S-phase progression. Brent Derry: Regulation of p53 by multiple SCF-based E3 ligases in C. elegans. Catarina Grandela: Regulation of apoptosis of by p53 in human embryionic stem cells. Paolo Salomoni: The role […]
8.45-11.00 BH3 molecules (Andreas Villunger and Philippe Bouillet) Philippe Bouillet: Mouse models to decipher the role of the BH3-only proteins in triggering apoptosis. Verana Labi: The BH3-only protein Bmf has overlapping functions with Bim during cell death induction and B-cell development. Paul Ekert: Cell death provoked by loss of Interleukin-3 signalling is independent of Bad, Bim, and […]
9.00-11.00 Caspase Regulation and Targets Ina Lavrik: The role of two new c-FLIP proteins in life and death of cells. Aura Kaunisto: Specific phosphorylation regulates the ubiquitylation and turnover of c-FLIP(S) Christina Falschlehner: Caspase-3 and BID are differentially processed by Caspase-8 and Caspase-10. Rüdiger Arnold: The caspase-3 target HPK1: A Molecular Switch between Life and Death in Hematopoietic Cells. […]
9.00-11.15 Death in Cancer (Jan Paul Medema and Ricky Johnstone) Ricky Johnstone: Defining the apoptotic pathways underlying histone deacytelase inhibitor-mediated tumor therapy. Elza de Bruin: Role of intrinsic and radiotherapy-induced apoptosis in rectal cancer patients. Dario Lombardi: Cytotoxic activity of normal and cancer neural stem cells through the production of death receptor ligands. Arturo Sala: The double life […]
7.30 – 9.00: Breakfast 9.00 – 11.00: Caspases and their Substrates (Vincenzo De Laurenzi and Andreas Villunger) Seamus Martin: Understanding the demolition phase of apoptosis. Antoine Tinel: Identification of a caspase-2 activating complex. Thomas Hofmann: FLASH links CD95 (Fas/APO-1) signaling to a novel PML-nuclear body-associated apoptosis pathway. Maya Saleh: Differential modulation of endotoxin responsiveness by […]