09.00 – 10.15 New mechanistic insights in tumorigenesis (III) Chairs: Vincenzo de Laurenzi, Giorgio Stassi 09.00 – 09.15 Alice Turdo: Role of Sam68 in modulating the tumorigenic and metastatic potential of breast Cancer Stem Cells 09.15 – 09.30 Simone Di Franco: p63 role in breast cancer progression 09.30 – 09.45 Annika Baude: LEDGF promotes DNA end resection and efficient […]
9.00 – 11.00 New mechanistic insights in tumorigenesis (I) Chairs: Ulrich Maurer, Michael Hahne 09.00 – 09.15 Valeria Lascano: APRIL enhances tumor formation in mouse models of colorectal cancer and correlates with poor survival of patients 09.15 – 09.30 Martijn H.A. van Attekum: TNF-family members BAFF and APRIL confer survival and drug resistance in Chronic Lymphocytic Leukemia […]
9.00 – 11.00 Inflammation Chairs: Seamus Martin, Henning Walczak 09.00 – 09.15 Introduction by Seamus J. Martin 09.15 – 09.30 Seamus J. Martin: Interactions between dying cells and the immune system 09.30 – 09.45 W. Wei-Lynn Wong: Inflammation before Death: Cytokine regulation by IAPs and RIPKs 09.45 – 10.00 Tom Vanden Berghe: Systematic analysis of inflammatory and cell […]
8.45 – 10.15 Bcl-2 family Chairs: P. Ekert 08.45 – 09.00 Introduction by Paul Ekert 09.00 – 09.15 Paul Ekert: Novel Mechanisms Regulating Bcl-2 protein family expression 09.15 – 09.30 Thomas Kaufmann: Towards understanding the functions of the Bcl-2 family member Bok 09.30 – 09.45 Ana Garcia Saez: Differences in the mechanism of membrane permeabilization by Bax and Bcl-xL […]
9:00am – 10:45am Session XI: Anti-cancer treatments (Mahvash Tavassoli) Marion MacFarlane A TRAIL-R1-specific Ligand in combination with Doxorubicin selectively targets Primary Breast Tumour Explants for Apoptosis Ricky W Johnstone Molecular characterisation of HDAC inhibitor-induced death in a mouse model of acute myeloid leukaemia Catarina Grandela Strategies to target and eradicate Colon Cancer Stem Cells Helen M. Beere Inhibition of […]
9:00am – 10:30am Session VII: Apoptosis and ubiquitin (Henning Walczak) Pascal Meier Regulation of apoptosis by ubiquitin and ubiquitin-like proteins Mike Hupe cIAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitmen Inge Verbrugge MARCH ubiquitin ligases dictate TRAIL-Receptor 1 membrane expression and TRAIL sensitivity in human tumor cells Christophe Le Clorennec The Role of the new […]
9:00am – 10:30am Session V: Bcl2-family in development (Katja Simon) Eric Eldering Darwinistic selection following T cell activation: the Noxa/Mcl-1 axis constitues a survival threshold set by TCR affinity and IL-2 signaling Felix M. Wensveen BH3-only protein Noxa mediates selection of high-affinity clones during antigen-driven interclonal B cell competition Daniela Bertele The role of pro-apoptotic BH3-only proteins during […]
9:00am – 10:45am Session I: IAPs in ubiquitin-mediated signaling (Mads Gyrd-Hansen) John Silke The General Theory of TNF Signalling Relativity Stefanie Cordier Identification of Sharpin as a novel functionally important component of the TNF-R1 and CD40 receptor signalling complexes Martin Leverkus The role of cIAPs for cell death signalling by membrane-bound receptors Maurice Darding Regulation of cIAP1’s E3-ligase activity. […]
7:00 – 9:00 Breakfast 9:00 – 10:30 Autophagy (Katja Simon / Eric Baehrecke) Maria Høyer-Hansen: Identifying proteins in the autophagosomes by a proteomic approach Devrim Gozuacik: Death-associated protein kinase (DAPk) is an integrator of apoptosis and autophagic cell death Kevin M. Ryan: Identifying the factors that determine specificity in the autophagy response Elisabetta Ferraro: Apoptosome–deficient cells lose cytochrome c […]