8:30-9:00 Registration
9:15-9:30 Welcome address
9:30-10:45 -Session 1- CELL DEATH AND CANCER PROGRESSION
Chairs: Vincenzo De Laurenzi/ Michael Hahne
– Majorini Maria Teresa -Cellular inhibitor of apoptosis 1 (cIAP1)-mediated regulation of Snai2 in breast cancer metastatization.
– Fehrenbacher Nicole -Identification of GPR31 as a Novel Mediator of Kras Membrane-Association
– Kumar Gunjan– A urine chondroitin sulfate detection system informs on bladder cancer disease burden to predict efficacy of VAR2-based cytotoxic targeting strategies.
– Ausserlechner Michael– Nuclear, PKB-phosphorylated FOXO3 predicts adverse clinical outcome and promotes tumorangiogenesis of neuroblastoma tumors in vivo
– Rafn Bo -Oncogenic tyrosine kinase regulation of ROS in epithelial cells
10:45-11:15 Coffee Break
11:15-12:45 -Session 2- CELL DEATH AND CANCER PROGRESSION -2
Chairs: Jan Paul Medema / Gianluca Sala
– Daugaard Mads -Oncofetal glycosaminoglycans in cancer
– Schoeler Katia -Apoptosis via the miR-17~92-Bim axis in Development and Cancer
– Sorensen Poul -YB-1 regulates metabolic adaptation and cancer progression through selective mRNA translation
– Leeksma Alexander – SF3B1 mutations in cancer lead to an altered DNA damage response, and splice products that are substrates for nonsense-mediated decay
– Giammona Alessandro Characterization of subcutaneous and visceral adipose-derived stem cells and their function in colon cancer.
– Aaboe Jensen Mads -RNA Therapeutics – developing a new class of drugs
13:00-15:00 Lunch
15:00-16:15 -Session 3- TNF family members and cancer
Chairs: Michael Hahne / Mads Daugaard
– Bertrand Mathieu JM -N-glycosylation of TRAIL-R restrains the sensitivity to TRAIL-induced apoptosis
– Peall Adam– Investigating the Mechanism of Protein Kinase C-mediated Inhibition of TRAIL-Induced Apoptosis
– Iurlaro Raffaella – Glucose deprivation induces FADD and caspase-8 dependent apoptosis through ATF4-mediated TRAIL-R2/DR5 up-regulation
– Manfroi Benoît – Tumor-derived CXCL-8 recruits APRIL-producing neutrophils in diffuse large B-cell lymphoma lesions
– van Attekum Martijn -Macrophages induce chronic lymphocytic leukemia cell survival via translational MCL-1 stabilization, independent of APRIL signaling
16:15-16:45 Coffee Break
16:45-18:30 -Session 4- Targeted cancer therapy
Chairs: Giorgio Stassi/Ulrich Maurer
– Pérez Silva Laura– Targeted melanoma therapeutics contribute to tumor relapse
– Del Mistro Greta– Impact of sublethal drug doses on melanoma cell behavior and tumor relapse
– Roca Maria Serena – Synergistic antitumor activity of histone deacetylase inhibitors and anti-ErbB3 antibody in NSCLC primary cultures via modulation of ErbB receptors expression.
– Sala Gianluca – HER-3: hub for escape mechanisms
– Babcook John -Translating Cancer Target Discovery Into Drugs
– Tabero Andrea – New combinational strategies to increase cell death in Photodynamic Therapy
– Martín-Antonio Beatriz Transfer of histone variant H2AZ from cord blood derived NK cells (CB-NK) to multiple myeloma cells (MM) is cytotoxic for MM cells. This cytotoxicity can be independent of CB-NK
19:30 Dinner