loading

8:30-9:00 Registration

9:15-9:30 Welcome address

9:30-10:45 -Session 1- CELL DEATH AND CANCER PROGRESSION

Chairs: Vincenzo De Laurenzi/ Michael Hahne

– Majorini Maria Teresa -Cellular inhibitor of apoptosis 1 (cIAP1)-mediated regulation of Snai2 in breast cancer metastatization.

– Fehrenbacher Nicole -Identification of GPR31 as a Novel Mediator of Kras Membrane-Association

– Kumar Gunjan– A urine chondroitin sulfate detection system informs on bladder cancer disease burden to predict efficacy of VAR2-based cytotoxic targeting strategies.

– Ausserlechner Michael– Nuclear, PKB-phosphorylated FOXO3 predicts adverse clinical outcome and promotes tumorangiogenesis of neuroblastoma tumors in vivo

– Rafn Bo -Oncogenic tyrosine kinase regulation of ROS in epithelial cells

 

10:45-11:15  Coffee Break

11:15-12:45 -Session 2- CELL DEATH AND CANCER PROGRESSION -2

Chairs: Jan Paul Medema / Gianluca Sala

– Daugaard Mads -Oncofetal glycosaminoglycans in cancer

– Schoeler Katia -Apoptosis via the miR-17~92-Bim axis in Development and Cancer

– Sorensen Poul -YB-1 regulates metabolic adaptation and cancer progression through selective mRNA translation

– Leeksma Alexander – SF3B1 mutations in cancer lead to an altered DNA damage response, and splice products that are substrates for nonsense-mediated decay

– Giammona Alessandro  Characterization of subcutaneous and visceral adipose-derived stem cells and their function in colon cancer.

– Aaboe Jensen Mads -RNA Therapeutics – developing a new class of drugs

 

13:00-15:00 Lunch

15:00-16:15 -Session 3- TNF family members and cancer

Chairs: Michael Hahne / Mads Daugaard

– Bertrand Mathieu JM -N-glycosylation of TRAIL-R restrains the sensitivity to TRAIL-induced apoptosis

– Peall Adam– Investigating the Mechanism of Protein Kinase C-mediated Inhibition of TRAIL-Induced Apoptosis

– Iurlaro Raffaella – Glucose deprivation induces FADD and caspase-8 dependent apoptosis through ATF4-mediated TRAIL-R2/DR5 up-regulation

– Manfroi Benoît – Tumor-derived CXCL-8 recruits APRIL-producing neutrophils in diffuse large B-cell lymphoma lesions

– van Attekum Martijn -Macrophages induce chronic lymphocytic leukemia cell survival via translational MCL-1 stabilization, independent of APRIL signaling

 

16:15-16:45 Coffee Break

16:45-18:30 -Session 4- Targeted cancer therapy

Chairs: Giorgio Stassi/Ulrich Maurer

– Pérez Silva Laura– Targeted melanoma therapeutics contribute to tumor relapse

– Del Mistro Greta Impact of sublethal drug doses on melanoma cell behavior and tumor relapse

– Roca Maria Serena – Synergistic antitumor activity of histone deacetylase inhibitors and anti-ErbB3 antibody in NSCLC primary cultures via modulation of ErbB receptors expression.

– Sala Gianluca – HER-3: hub for escape mechanisms

– Babcook John -Translating Cancer Target Discovery Into Drugs

– Tabero Andrea – New combinational strategies to increase cell death in Photodynamic Therapy

– Martín-Antonio Beatriz Transfer of histone variant H2AZ from cord blood derived NK cells (CB-NK) to multiple myeloma cells (MM) is cytotoxic for MM cells. This cytotoxicity can be independent of CB-NK

19:30 Dinner