Thursday April 7
9:15-10:45 -Session 10- CELL DEATH IN NON MALIGNANT DISEASE Chairs: Katja Simon/ Marion McFarlane – Desangher Solange -Characterization of a novel pathway regulating α-synuclein expression and neuronal death in Parkinson’s disease – Granzotto Alberto -Pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of alzheimer’s disease without reducing amyloid and tau pathology – Delgado M.Eugenia -LRH-1-dependent regulation […]
Wednesday April 6
9:15-10:45 -Session 8- CELL DEATH AND INFLAMMATION Chairs: Julian Pardo/John Silke – Martin Seamus – IL-1 family cytokines as the canonical DAMPs and their interplay with neutrophil-derived proteases – Clancy Danielle -Neutrophil-derived proteases act as amplifiers of inflammation through processing and activation of multiple IL-1 family cytokines. – Conos Stephanie -Cell death is not essential for caspase-1 mediated […]
Tuesday April 5
9:30-10:45 -Session 5- Cancer therapy Chairs: Gerry Melino/Anastasis Stephanou – Ellegaard Anne Marie-Repurposing cationic amphiphilic antihistamines for cancer treatment – Jaime Paula -Immunogenicity of cytotoxic T cell-mediated cell death during cancer immunotherapy and its regulation by mutations associated with apoptosis resistance. – Zimberlin Cheryl– Histone deacetylase (HDAC) inhibitors activate FOXOs in order to differentiate and sensitize colon cancer […]
Monday April 4
8:30-9:00 Registration 9:15-9:30 Welcome address 9:30-10:45 -Session 1- CELL DEATH AND CANCER PROGRESSION Chairs: Vincenzo De Laurenzi/ Michael Hahne – Majorini Maria Teresa -Cellular inhibitor of apoptosis 1 (cIAP1)-mediated regulation of Snai2 in breast cancer metastatization. – Fehrenbacher Nicole -Identification of GPR31 as a Novel Mediator of Kras Membrane-Association – Kumar Gunjan– A urine chondroitin sulfate detection […]
Thursday, April 3
Cancer Chairs: Vincenzo diLaurenzi & Jan-Paul Medema 9:00 Michael Hahne: The tubulin glycylase TTLL3 links primary cilia to colon cancer development 9:15 Paul A Townsend: Effect of histone deacetylase inhibitors on Notch signalling in the epidermis 9:30 Erik Slinger: CLL development is accelerated in mice deficient for pro-apoptotic regulator Noxa 9:45 Monika Mortensen: Targeting the autolysosomal compartment to improve […]
Wednesday, April 2
Death receptor signaling and IAPs Chairs: Martin Leverkus & Giorgio Stassi 9:00 Mathieu JM Bertrand: An NF-kB-independent role of IKKs in regulating RIPK1 killing potential 9:15 Rebecca Feltham: MIB and SOB1 are novel RIPK1 interacting molecules that regulate TNF signaling by controlling the balance between survival and death 9:30 Thomas Grabinger: Mechanisms of TNF induced cell death in […]
Tuesday, April 1
Autophagy and the lysosome Chairs: Monika Mortensen & Cristina Munoz-Pinedo 9:00 Monika Mortensen: short introduction 9:10 Tom Riffelmacher: Autophagy controls terminal differentiation of neutrophils 9:25 Anne Louise Hansen: Autophagy controls inflammation in the aging organism 9:40 Ghadir Almuhaini: HPV E6 Modulation of Autophagy 9:55 Sonja Aits: Galectins-1 as a novel marker for lysosomal membrane permeabilization 10:10 Søren Høgh: Regulation of lysosomal […]
Monday, March 31
BCL2 family and mitochondria Chairs: Andreas Villunger & Thomas Kaufmann 9:00 Welcome 9:05 Andreas Villunger: Introduction 9:15 Andreas Villunger: BH3-only proteins Bim and Bmf limit B cell survival in the absence of BAFF 9:30 Gabriel Ichim: Failure to execute apoptosis results in mitochondrial dependent DNA damage 9:45 Raquel Salvador Gallego: Microscopy […]